A UFC Heavyweight Championship bout between Francis Ngannou and Present champion Stipe Miocic Functioned as If headliner.
The episode also featured a UFC Light Heavyweight Championship bout between current champion Daniel Cormier and Volkan Oezdemir. 
A welterweight bout between The Ultimate Fighter: American Top Team vs. Blackzilians welterweight winner Kamaru Usman and Emil Weber Meek was originally scheduled for UFC 219. However, due to an alleged visa dilemma for Meek which affected his travel program, the pairing was delayed and then rescheduled to this event.  However, it was shifted to UFC Fight Night: Stephens vs. Choi a day after, that took place six days before this event. 
A welterweight bout between Abdul Razak Alhassan and Sabah Homasi was initially scheduled for UFC 219, but later altered for this event. When Alhassan acquired via a TKO that was controversial, the pairing met at UFC 218. 
Charles Rosa was anticipated to confront newcomer Dan Ige. On December 22, Rosa pulled due to a neck injury.  Ige remained on the card and faced fellow newcomer Julio Arce. 
Arnold Allen was anticipated to confront The Ultimate Fighter: Latin America 2 lightweight winner Enrique Barzola in the occasion. However, Allen was pulled from the fight on January 11 due to alleged visa problems which restricted his ability to travel.  He had been replaced by newcomer Matt Bessette that is promotional. 
Jamie Moyle was expected to confront Maryna Moroz in the occasion. However, Moyle pulled from the fight through the week leading up to case citing an undisclosed injury.  In turn, advertising officials indicated that Moroz would be rescheduled for a future event.
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